Learn Different TYPES OF INSULIN & HOW To MIX It Correctly

Types of Insulin and Mixing

Rapid Acting Insulin

Begins to work 5 -15 minutes after injection, peaks in about 1 hour and continue to work for 2-4 hours

Used to control blood sugar levels during meals and snacks and correct high blood sugar

Mix Humalog or Novolog with other insulin types, but mix Apidra only with NPH insulin, if needed. Administer immediately after mixing

While mixing rapid-acting insulin with a longer-acting insulin, always draw rapid-acting insulin first into the syringe to avoid dosage error

Eg:- Humalog(Insulin lispro), Novolog(insulin aspart), Apidra(Insulin glulisine)

Regular or Short-Acting Insulin

Reaches the bloodstream about 30 minutes after the injection, peaks anywhere from 2 – 3 hours after the injection and is effective for approximately 3 – 6 hours

Used to control blood sugar levels during meals and snacks and correct high blood sugar levels

Administer SubQ, IM or IV, as prescribed

Eg:- Regular insulin(Humulin R, Novolin R)

Intermediate-Acting Insulin

Reaches the bloodstream about 2 -4 hours after injection, peaks 4 -12 hours and is effective for about 12 – 18 hours

Absorbed more slowly and lasts longer, which is why it is used to control blood sugar levels overnight while fasting and between meals

Eg:- NPH insulin(Novolin NPH, Humulin N)

Long-Acting Insulin

Reaches the bloodstream several hours after injection and tends to lower glucose levels fairly evenly over a 24-hour period

Absorbed slowly, has a minimal peak effect and then a stable plateau effect that lasts most of the day used to control blood sugar overnight while fasting between meals

Administer SubQ route only

Eg:- Lantus(Insulin glargine), Levemir(insulin detemir), Humulin U

Mixing of Insulin

Administer 12 units of regular insulin and 30 units of NPH insulin

The mneomonic is RN

Always Withdraw regular insulin first then NPH

Demonstration of Mixing of Insulin

Step 1

Inject 30 units of air into NPH Insulin vial

Step 2

Inject 12 units of air into regular insulin

Step 3

Withdraw 12 units of regular insulin first

Step 4

Withdraw 30 units of NPH insulin

Special Precaution:-

  • Do not mix Lantus or Levemir with another insulin or solution
  • Administer a combination insulin subQ route only eg:- Humulin 70/30, Novolin 70/30
  • Do not use insulin if it contains precipitate that is clumped or granular or that clings to the sides of the vial
  • Roll the vial gently between your palms to mix, do not shake it

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